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Loureirin B

Catalog No. T3876 CAS 119425-90-0

Synonyms: 龙血素 B, 龙血素B

Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.

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Loureirin B, CAS 119425-90-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
Targets&IC50	PAI-1:26.10 μM

Synonyms	龙血素 B, 龙血素B
Molecular Weight	316.353
Formula	C18H20O5
CAS No.	119425-90-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 150 mg/mL (474.16 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24(5):355-60. 2. Yin S, et al. Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells. Cell Biosci. 2014 Dec 12;4:78.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Anti-Cancer Metabolism Compound Library Traditional Chinese Medicine Monomer Library Anti-Obesity Compound Library Glutamine Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Natural Product Library for HTS Ion Channel Inhibitor Library Anti-Tumor Natural Product Library

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Related compounds with same targets

Shizukaol B Manassantin B Isoangustone A Ganoderic acid X 3,5-Dicaffeoyl-epi-quinic acid 15-Methoxypinusolidic acid Panaxydol Lucidenic acid F

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Keywords

Loureirin B 119425-90-0 MAPK信号通路代谢离子通道 JNK ERK PAI-1 Potassium Channel Inhibitor inhibit KcsA Plasminogen activator inhibitor-1 Extracellular signal regulated kinases inhibitor

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