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Loxiglumide

Loxiglumide
Loxiglumide (CR-1505) is an antagonist of cholecystokinin (CCK-1) receptor.
Catalog No. T2312Cas No. 107097-80-3
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Purity:99.81%
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Loxiglumide

Purity: 99.81%
Catalog No. T2312Alias CR-1505Cas No. 107097-80-3

Loxiglumide (CR-1505) is an antagonist of cholecystokinin (CCK-1) receptor.
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Pack SizePriceAvailabilityQuantity
10 mg$34In Stock
25 mg$71In Stock
50 mg$125In Stock
100 mg$212In Stock
200 mg$365In Stock
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Product Introduction

Bioactivity
Description
Loxiglumide (CR-1505) is an antagonist of cholecystokinin (CCK-1) receptor.
Kinase Assay
Kinase binding assays: For optimization of Axl/TAM receptor inhibitors, an Axl binding assay is established (HTRF method; Kinase tracer 236). This assay is based on the binding and displacement of the Alexa Fluor 647-labelled Kinase tracer 236 to each glutathione S-transferase (GST)-tagged kinase used in the binding assay. Binding of the tracer to the kinase was detected by using europium (Eu)-labelled anti-GST antibodies. Simultaneous binding of both the fluorescent tracer and the Eu-labelled antibodies to the GST-tagged kinase generates a fluorescence resonance energy transfer (FRET) signal. Binding of inhibitor to the kinase competes for binding with the tracer, resulting in a loss of the FRET signal. For the assay, the compound is diluted in 20?mM HEPES, pH?8.0, 1?mM DTT, 10?mM MgCl2 and 0.01% Brij35. Then, the kinase of interest (5?nM final concentration), fluorescent tracer (15?nM final concentration) and LanthaScreen Eu-anti-GST antibody (2?nM final concentration) are mixed with the respective compound dilutions (from 5?nM to 10?μM) and incubated for 1?h. The FRET signal is quantified using an EnVision Multilabellreader 2104.
AliasCR-1505
Chemical Properties
Molecular Weight461.38
FormulaC21H30Cl2N2O5
Cas No.107097-80-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.61 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1674 mL10.8371 mL21.6741 mL108.3705 mL
5 mM0.4335 mL2.1674 mL4.3348 mL21.6741 mL
10 mM0.2167 mL1.0837 mL2.1674 mL10.8371 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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