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Luteolin

Catalog No. T1027   CAS 491-70-3
Synonyms: Luteolol, Flacitran, Digitoflavone, Luteoline

Luteolin (Luteolol) is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior. Furthermore, some studies have reported the impairment of in vivo angiogenesis by dietary flavonoids. Experimental animal studies indicate that certain dietary flavonoids possess antitumoral activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Luteolin Chemical Structure
Luteolin, CAS 491-70-3
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
50 mg In stock $ 45.00
100 mg In stock $ 55.00
200 mg In stock $ 86.00
500 mg In stock $ 148.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 98%
Purity: 97.39%
Purity: 96.61%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Luteolin (Luteolol) is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior. Furthermore, some studies have reported the impairment of in vivo angiogenesis by dietary flavonoids. Experimental animal studies indicate that certain dietary flavonoids possess antitumoral activity.
Targets&IC50 PDE2:6.4 μM(Ki), PDE3:13.9 μM(Ki), PDE5:9.5 μM(Ki), PDE1:15.0 μM(Ki), PDE4:11.1 μM(Ki)
Synonyms Luteolol, Flacitran, Digitoflavone, Luteoline
Molecular Weight 286.24
Formula C15H10O6
CAS No. 491-70-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 57 mg/mL (199.13 mM)

Ethanol: 3 mg/mL (10.48 mM), warmed

TargetMolReferences and Literature

1. Yu MC, et al. Eur J Pharmacol, 2010, 627(1-3), 269-275. 2. Xagorari A, et al. J Pharmacol Exp Ther, 2001, 296(1), 181-187. 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019. 4. Dong J, Xu O, Wang J, et al. . Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats[J]. Immunopharmacology and Immunotoxicology. 2021: 1-9 5. Ding X, Zheng L, Yang B, et al. Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response[J]. Drug Des Devel Ther. 2019, 13: 3899. 6. Yang Y, Tan X, Xu J, et al. Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage[J]. Biomedicine & pharmacotherapy. 2020, 126: 110044. 7. Tan X, Yang Y, Xu J, et al. Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage[J]. Frontiers in Pharmacology. 2020, 10: 1551.

TargetMolCitations

1. Tan X, Yang Y, Xu J, et al. Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage. Frontiers in Pharmacology. 2020, 10: 1551 2. Yang Y, Tan X, Xu J, et al. Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage. Biomedicine & Pharmacotherapy. 2020, 126: 110044 3. Zhang Y, Yu F, Hao J, et al. Study on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice. Frontiers in Veterinary Science. 2021, 8. 4. Ding X, Zheng L, Yang B, et al. Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response. Drug Des Devel Ther. 2019, 13: 3899. 5. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135 6. Xiao Z, Xu H, Qu Z, et al. Active Ingredients of Reduning Injections Maintain High Potency against SARS-CoV-2 Variants. Chinese Journal of Integrative Medicine. 2022: 1-8. 7. Dong J, Xu O, Wang J, et al.  Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats. Immunopharmacology and Immunotoxicology. 2021 Jun;43(3):319-327. doi: 10.1080/08923973.2021.1905659. Epub 2021 Apr 26. 8. Jung M A, Song H K, Jo K, et al.Gleditsia sinensis Lam. aqueous extract attenuates nasal inflammation in allergic rhinitis by inhibiting MUC5AC production through suppression of the STAT3/STAT6 pathway.Biomedicine & Pharmacotherapy.2023, 161: 114482. 9. Zhu Y, Bao G, Zhu G, et al.Discovery and characterization of natural product luteolin as an effective inhibitor of human pyridoxal kinase.Bioorganic Chemistry.2023: 107057.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Anti-Cancer Active Compound Library Antiparasitic Natural Product Library Anti-Neurodegenerative Disease Compound Library Tobacco Monomer Library Natural Product Library Metabolism Compound Library Bioactive Compound Library Ferroptosis Compound Library Cuproptosis Compound Library

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Keywords

Luteolin 491-70-3 Apoptosis Autophagy Immunology/Inflammation Metabolism Nrf2 Endogenous Metabolite PDE inhibit Keap1-Nrf2 Luteolol Flacitran Digitoflavone Inhibitor Luteoline inhibitor

 

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