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Luteolin

Luteolin
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Purity:98%
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Luteolin

Catalog No. T1027Cas No. 491-70-3
Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant.
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Pack SizePriceAvailabilityQuantity
10 mg$39In Stock
50 mg$45In Stock
100 mg$55In Stock
200 mg$86In Stock
500 mg$148In Stock
1 g$217In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Product Introduction

Bioactivity
Description
Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant.
In vitro
METHODS: ESCC cell lines EC1, EC9706, KYSE30 and KYSE450 were treated with Luteolin (10-80 µM) for 48-72 h. Cell viability was measured using the CCK-8 Assay.
RESULTS: Luteolin inhibited the growth of ESCC cell lines in a dose-dependent manner with IC50 in the range of 20-60 µM. [1]
METHODS: Human cervical cancer cells, HeLa, were treated with Luteolin (5-20 µM) for 48 h. Cell cycle profiles were analyzed using Flow Cytometry.
RESULTS: Luteolin treatment blocked the cell cycle progression of HeLa cells in sub-G1 phase. [2]
In vivo
METHODS: To detect anti-tumor activity in vivo, Luteolin (50 mg/kg) was injected intraperitoneally once daily for eighteen days into BALB/C-nu mice bearing ESCC tumor EC1.
RESULTS: The Luteolin treatment group showed a reduction in tumor size and a reduction in total tumor weight of about 65%. [1]
METHODS: To study the effect on intestinal mucositis, Luteolin (3-30 mg/kg in water plus 1% Tween) was administered by gavage or intraperitoneally to irinotecan-induced intestinal mucositis in Swiss mice once a day for fourteen days.
RESULTS: Luteolin prevented irinotecan-induced intestinal damage by reducing weight loss and diarrhea scores as well as attenuating duodenal and colonic shortening. [3]
AliasLuteolol, Flacitran, Digitoflavone, Luteoline
Chemical Properties
Molecular Weight286.24
FormulaC15H10O6
Cas No.491-70-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (192.15 mM)
Ethanol: 3 mg/mL (10.48 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.4936 mL17.4679 mL34.9357 mL174.6786 mL
5 mM0.6987 mL3.4936 mL6.9871 mL34.9357 mL
10 mM0.3494 mL1.7468 mL3.4936 mL17.4679 mL
DMSO
1mg5mg10mg50mg
20 mM0.1747 mL0.8734 mL1.7468 mL8.7339 mL
50 mM0.0699 mL0.3494 mL0.6987 mL3.4936 mL
100 mM0.0349 mL0.1747 mL0.3494 mL1.7468 mL

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