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Lys-[Des-Arg9]Bradykinin acetate

Catalog No. TP1918L1 CAS TP1918L1

Synonyms: Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base)

Lys-[Des-Arg9]Bradykinin acetate is an endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and < 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]-Bradykinin.

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Lys-[Des-Arg9]Bradykinin acetate Chemical Structure

Lys-[Des-Arg9]Bradykinin acetate, CAS TP1918L1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 81.00
5 mg	In stock	$ 183.00
10 mg	In stock	$ 275.00
25 mg	In stock	$ 503.00
50 mg	In stock	$ 728.00
100 mg	In stock	$ 1,030.00

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Purity: 99.93%

Biological Description

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Storage & Solubility Information

Description	Lys-[Des-Arg9]Bradykinin acetate is an endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]-Bradykinin.
Targets&IC50	Bradykinin B1:0.12 nM at human, Bradykinin B2: > 30000 nM at human

Synonyms	Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base)
Molecular Weight	1092.27
Formula	C52H77N13O13
CAS No.	TP1918L1

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 2. Regoli et al (2001) Classification of kinin receptors. Biol.Chem. 382 31 PMID: 3. Leeb-Lundberg et al (2005) International union of pharmacology. LV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID:

Citations

1. Xiao F, Jiang H, Li Z, et al.Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice.Nature Communications.2023, 14(1): 2523.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library GPCR Compound Library Membrane Protein-targeted Compound Library Peptide Compound Library

Related Products

Related compounds with same targets

Icatibant Acetate ELN-441958 Bradykinin (acetate) R715 TFA(185052-09-9 free base) Lys-[Des-Arg9]Bradykinin,TFA Lys-(Des-Arg9,Leu8)-Bradykinin Sar-[D-Phe8]-des-Arg9-Bradykinin acetate [Des-Arg9]-Bradykinin

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Keywords

Lys-[Des-Arg9]Bradykinin acetate TP1918L1 GPCR/G Protein Bradykinin Receptor Lys-[Des-Arg9]Bradykinin Acetate Lys-[Des-Arg-9]Bradykinin acetate 71800-36-7 71800-36-7 free base Lys [Des Arg9]Bradykinin acetate Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base) Lys[DesArg9]Bradykinin acetate inhibitor inhibit

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