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MK-0674

TargetMol
Catalog No. T16089Cas No. 887781-62-6

MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.

MK-0674

MK-0674

TargetMol
Purity: 100%
Catalog No. T16089Cas No. 887781-62-6
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
Pack SizePriceAvailabilityQuantity
1 mg$490In Stock
2 mg$728In Stock
5 mg$1,130In Stock
10 mg$1,530In Stock
25 mg$2,270In Stock
50 mg$2,980In Stock
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Purity:100%
ee:96.61%
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Product Introduction

Bioactivity
Description
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
Targets&IC50
Cathepsin K:0.4 nM
In vitro
MK-0674, as an orally bioavailable tissue protease K inhibitor, is capable of acting on rabbit osteoclasts with an IC50 of 10 nM[1].
Chemical Properties
Molecular Weight527.5
FormulaC26H27F6N3O2
Cas No.887781-62-6
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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