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ML-109

ML-109
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
Catalog No. T12073Cas No. 1186649-91-1
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Purity:98.14%
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ML-109

Purity: 98.14%
Catalog No. T12073Cas No. 1186649-91-1

ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$73In Stock
25 mg$148In Stock
50 mg$238In Stock
100 mg$355In Stock
200 mg$496In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Product Introduction

Bioactivity
Description
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
Targets&IC50
TSHR:40 nM(EC50)
In vitro
ML-109 is a full agonist at TSHR with an EC50 of 40 nM ,has no activity at FSHR or LHCGR.
Chemical Properties
Molecular Weight523.58
FormulaC31H29N3O5
Cas No.1186649-91-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 83.33 mg/mL (159.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9099 mL9.5496 mL19.0993 mL95.4964 mL
5 mM0.3820 mL1.9099 mL3.8199 mL19.0993 mL
10 mM0.1910 mL0.9550 mL1.9099 mL9.5496 mL
20 mM0.0955 mL0.4775 mL0.9550 mL4.7748 mL
50 mM0.0382 mL0.1910 mL0.3820 mL1.9099 mL
100 mM0.0191 mL0.0955 mL0.1910 mL0.9550 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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