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MMAF Hydrochloride
Catalog No. T16121Cas No. 1415246-68-2
Alias Monomethylauristatin F Hydrochloride
MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound.
MMAF Hydrochloride
Catalog No. T16121Alias Monomethylauristatin F HydrochlorideCas No. 1415246-68-2
MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | Inquiry | 1-2 weeks | |
| 50 mg | Inquiry | 1-2 weeks | |
| 100 mg | Inquiry | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound. |
| In vitro | MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4]. |
| In vivo | cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats, whereas the cAC10-L4-MMAF4 ADC is much less toxic, with MTDs of >150 mg/kg in mice and 90 mg/kg in rats. The maximum tolerated dose of MMAF (>16 mg/kg) in mice is much higher than that of MMAE (1 mg/kg) [4]. |
| Alias | Monomethylauristatin F Hydrochloride |
| Molecular Weight | 768.42 |
| Formula | C39H66ClN5O8 |
| Cas No. | 1415246-68-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 27 mg/mL (35.14 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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