Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MRT-83 is a potent Smo antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
2 mg | In stock | $ 63.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 322.00 | |
50 mg | In stock | $ 555.00 | |
100 mg | In stock | $ 783.00 | |
500 mg | In stock | $ 1,650.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 115.00 |
Description | MRT-83 is a potent Smo antagonist. |
In vitro | MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays[1]. |
In vivo | MRT-83 can't up-regulation of Ptc transcription in the SVZ of these animals in agreement with complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects[1]. |
Molecular Weight | 538.59 |
Formula | C31H30N4O5 |
CAS No. | 1263131-92-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (464.17 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MRT-83 1263131-92-5 Stem Cells Smo MRT83 Inhibitor MRT 83 inhibit Smoothened inhibitor