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MS402

Catalog No. T12112 CAS 1672684-68-2

MS402 is a novel BD1-selective BET BrD inhibitor.

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MS402, CAS 1672684-68-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 42.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 312.00
100 mg	In stock	$ 531.00
1 mL * 10 mM (in DMSO)	In stock	$ 75.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MS402 is a novel BD1-selective BET BrD inhibitor.
Targets&IC50	BRD3 BD1:110 nM (Ki), BRD4 BD2:718 nM (Ki), BRD4 BD1:77 nM (Ki), BRD3 BD2:200 nM (Ki), BRD2 BD2:240 nM (Ki), BRD2 BD1:83 nM (Ki)
In vitro	MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation. Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment.

Molecular Weight	370.83
Formula	C20H19ClN2O3
CAS No.	1672684-68-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (60.67 mM)

References and Literature

1. Cheung K, et al. BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Histone Modification Compound Library Bioactive Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library Reprogramming Compound Library Immunology/Inflammation Compound Library PPI Inhibitor Library NO PAINS Compound Library Epigenetics Compound Library

Related Products

Related compounds with same targets

PROTAC BRD3/BRD4-L degrader-2 MS436 CPI203 IACS-9571 Hydrochloride (1800477-30-8 free base) BRM/BRG1 ATP Inhibitor-1 NSC 228155 Piflufolastat A1874

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MS402 1672684-68-2 Chromatin/Epigenetic Epigenetic Reader Domain inhibit Inhibitor MS-402 MS 402 inhibitor

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