Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 40.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 162.00 | |
50 mg | In stock | $ 238.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM). |
Targets&IC50 | PDE5:1.3 μM (Ki), PDE5:6.7 μM , PDE4:37 μM |
In vitro | in ABCG2-overexpressing cells, MY-5445 selectively reverses ABCG2-mediated multidrug resistance. MY-5445 reverses ABCG2-mediated multidrug resistance (MDR) by potentiating the cytotoxicity of an ABCG2 substrate drug in ABCG2-overexpressing multidrug-resistant cancer cells, possibly by modulating the function and/or the protein expression of ABCG2[2]. In the S1-M1-80 cell, MY-5445 (3 μM; 48 hours) substantially increases the topotecan-induced apoptosis[2]. |
In vivo | I.p administration of 0.5-3 mg/kg twice a day for 15 days) produces significant relief of mechanical hypersensitivity[3]. |
Synonyms | N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
Molecular Weight | 331.8 |
Formula | C20H14ClN3 |
CAS No. | 78351-75-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (120.55 mM)
You can also refer to dose conversion for different animals. More
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MY-5445 78351-75-4 Metabolism PDE aggregation platelet Inhibitor anticancer inhibit N-(3-chlorophenyl)-4-phenylphthalazin-1-amine neuropathic MY 5445 Phosphodiesterase (PDE) neuropathic pain allodynia MY5445 inhibitor