Shopping Cart
- Remove All
Your shopping cart is currently empty
Argentina
Australia
Austria
Belgium
Brazil
Bulgaria
Croatia
Cyprus
Czech
Denmark
Egypt
Estonia
Finland
France
Germany
Greece
Hong Kong
Hungary
Iceland
India
Ireland
Israel
Italy
Japan
Korea
Latvia
Lebanon
Malaysia
Malta
Morocco
Netherlands
New Zealand
Norway
Poland
Portugal
Romania
Singapore
Slovakia
Slovenia
Spain
Sweden
Switzerland
Taiwan,China
Thailand
Turkey
United Kingdom
United States
Other Countries
Select your Country or Region
Macluraxanthone
Catalog No. TN5912Cas No. 5848-14-6
Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the polarization of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86 while decreasing their expression of CD14, CD11b and CD80. Macluraxanthone significantly reduced the production of TNF-α and IL-10 cytokines in the presence of the pro-inflammatory stimulant lipopolysaccharide.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,589 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $1,898 | Backorder |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Macluraxanthone"
TNF/IFNγ-IN-1
T83628876013-29-5
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.
- $195
Size
QTY
Mogroside IV-E
T830088915-64-4
Mogroside IV-E is a triterpenoid glycoside isolated from the extracts of Luo Han Guo. Mogrosides exhibit antidiabetic, antioxidant and anticancer activities.
- $44
Size
QTY
(±)-α-Bisabolol
T8199515-69-5
(±)-α-Bisabolol (Bisabolol) isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating, anti-inflammatory, antioxidant and anticancer activities. (±)-α-Bisabolol has anticancer effects on A549 NSC-LC cells by inducing cell cycle arrest, mitochondrial death and inhibiting PI3K/Akt signaling (IC50 = 15 μM). (±)-α-Bisabolol can induce apoptosis of glioma cells.
- Inquiry Price
Size
QTY
Gelsemine
Cited
T5S0662509-15-9
1. Gelsemine (Gelsemin) has antitumor activity. 2. Gelsemine has anti-oxidative activity. 3. Gelsemine has anti-hyperlipidemic activity. 4. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cancer pains without inducing antinociceptive tolerance.
- $47
Size
QTY
CitedEllagic acid (hydrate)
T8305314041-08-2
Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).
- $76
Size
QTY
Jaceidin
TN434310173-01-0
Jaceidin (Quercetagetin 3,3',6-trimethyl ether) is a membrane-permeable inhibitor of VEGFR with anti-tumor activities.
- $598
Size
QTY
4-Methylesculetin
TJS0338529-84-0
4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
- $30
Size
QTY
Purpurin 18
T1953125465-77-4
Purpurin 18 is an interesting dihydroporphyrin for generating photosensitizers. It has antioxidant activity
- $36
Size
QTY
2'-Hydroxy-3,4-dimethoxychalcone
TN722519152-36-4
2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular survival of Lactobacillus donovani Parasite EC.50 Values ranged between 0.39 and 0.41 μg/mL, which can be used in the study of diabetes, treatment of schistosomiasis, malaria and other infections.
- $50
Size
QTY
Macranthoside A
TN1831128730-82-5
Macranthoside A (Kalopanaxsaponin H) is a triterpenoid glycoside extracted from rehmannia and belongs to the iridoterpenoid synthesis. Macranthoside A has anti-inflammatory, antioxidant, antibacterial and neuroprotective activities, inhibits the production of pro-inflammatory cytokines and inhibits the activation of inflammatory signaling pathways, helps neutralize harmful free radicals, protects cells from oxidative damage, and promotes the survival and growth of neurons. And prevent neuronal cell death caused by oxidative stress or neurotoxic compounds, which has the potential to treat neurodegenerative diseases, cardiovascular diseases and liver damage.
- $293
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the polarization of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86 while decreasing their expression of CD14, CD11b and CD80. Macluraxanthone significantly reduced the production of TNF-α and IL-10 cytokines in the presence of the pro-inflammatory stimulant lipopolysaccharide. |
| In vitro | Macluraxanthone (3 and 10 μM), at non-toxic effective doses, significantly inhibited B16F10 cell invasion, to a greater extent than 10 μM doxorubicin, while reducing migration of cancer cells without cellular cytotoxicity. Our findings indicate for the first time that active macluraxanthone isolated from Maclura amboinensis Bl. roots affect multistep of cancer metastasis processes including proliferation, adhesion, invasion and migration, possibly through induction of apoptosis of highly metastatic B16F10 melanoma cells.[1] |
| In vivo | We investigated the in vivo therapeutic effects of the two xanthones in a xenograft murine model of human CLL, developed by engrafting CD5-transfected chronic leukemia B cells into SCID mice. Treatment of the animals with five daily injections of macluraxanthone (5 mg/kg) resulted in a significant prolongation of their survival as compared to control animals injected with the solvent alone (p = 0.0006 and p = 0.0141, respectively). These data show for the first time the in vivo antileukemic activities of two plant-derived xanthones.[2] |
| Alias | 3-Hydroxyblancoxanthone |
| Molecular Weight | 394.42 |
| Formula | C23H22O6 |
| Cas No. | 5848-14-6 |
| Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。 Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Dose Conversion
You can also refer to dose conversion for different animals. More
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.