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Maclurin

Catalog No. T20578 CAS 519-34-6

Synonyms: NSC 83240, Morintannic acid

Maclurin is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and can be used in studies about the prevention of many diseases or MSCs transplantation.

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Maclurin, CAS 519-34-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Maclurin is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and can be used in studies about the prevention of many diseases or MSCs transplantation.
In vitro	Maclurin effectively protects against mesenchymal stem cells (MSCs) oxidative damage induced by hydroxyl radical (OH) at 62.1-310.5 μM. Maclurin efficiently protects DNA from OH-induced damage at 114.6-382.2 μM, and scavenge OH, DPPH, ABTS(+), and bind Cu(2+) with IC50s of 122.87, 10.15, 0.97, and 133.95 μM[1].

Synonyms	NSC 83240, Morintannic acid
Molecular Weight	262.21
Formula	C13H10O6
CAS No.	519-34-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 4.8 mg/mL (18.31 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Li X, et al. Maclurin protects against hydroxyl radical-induced damages to mesenchymal stem cells: antioxidant evaluation and mechanistic insight. Chem Biol Interact. 2014 Aug 5;219:221-8. 2. Ku MJ, et al. Maclurin suppresses migration and invasion of human non-small-cell lung cancer cells via anti-oxidative activity and inhibition of the Src/FAK-ERK-β-catenin pathway. Mol Cell Biochem. 2015 Apr;402(1-2):243-52. 3. Lee YJ, Lee SY. Maclurin exerts anti-cancer effects in human osteosarcoma cells via prooxidative activity and modulations of PARP, p38, and ERK signaling. IUBMB Life. 2021 Aug;73(8):1060-1072. 4. Kim J, et al. Protective Effects of Maclurin against Benzo[a]pyrene via Aryl Hydrocarbon Receptor and Nuclear Factor Erythroid 2-Related Factor 2 Targeting. Antioxidants (Basel). 2021 Jul 26;10(8):1189.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Maclurin 519-34-6 Immunology/Inflammation Metabolism NF-Κb oxidation-reduction Free radical scavengers Reactive Oxygen Species NSC 83240 Morintannic acid Inhibitor inhibitor inhibit

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