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Marmin

Catalog No. TN1913 CAS 14957-38-1

Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.

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Marmin, CAS 14957-38-1

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Purity: 98%

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Description

In vitro

In the study, we examined the effects of Marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80. We also evaluated its action against contraction induced by extracellular or intracellular calcium ion. The possibility of Marmin to potentiate the relaxation effect of isoprenaline was also studied. Marmin added in the organ bath at 10 min prior to the agonist inhibited the contraction elicited by histamine and metacholine in a concentration-dependent manner. Moreover, Marmin antagonized the histamine-induced contraction in competitive manner. Marmin mildly potentiated the relaxation effect of isoprenaline. In the study, Marmin abrogated the contraction of tracheal smooth muscle induced by compound 48/80, an inducer of histamine release. Besides, Marmin successfully inhibited CaCl(2)-induced contraction in Ca(2+)-free Krebs solution. Marmin also inhibited two phases of contraction which were consecutively induced by metacholine and CaCl(2) in Ca(2+)-free Krebs solution[1]

Molecular Weight	332.39
Formula	C19H24O5
CAS No.	14957-38-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea.Pak J Pharm Sci. 2011 Oct;24(4):427-33.

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Keywords

Marmin 14957-38-1 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience Antifection Histamine Receptor Calcium Channel Inhibitor inhibitor inhibit

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