store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 158.00 | |
50 mg | In stock | Inquiry |
Description | Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. |
Synonyms | DM1, Maytansinoid DM1 |
Molecular Weight | 738.29 |
Formula | C35H48ClN3O10S |
CAS No. | 139504-50-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (112.87 mM)
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Mertansine 139504-50-0 Cytoskeletal Signaling Microtubule Associated Maytansinoid DM-1 Maytansinoid DM 1 melanoma DM1 Inhibitor B16F10 ADC Payload ADC Cytotoxin DM-1 DM 1 tubulin Microtubule/Tubulin Maytansinoid DM1 antiproliferative inhibit mitosis antitumor ADC inhibitor