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NF-1819

Catalog No. T28165Cas No. 1881244-28-5
Alias NF1819, NF 1819

NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.

NF-1819

NF-1819

Purity: 98.21%
Catalog No. T28165Alias NF1819, NF 1819Cas No. 1881244-28-5
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
Pack SizePriceAvailabilityQuantity
5 mg$58In Stock
10 mg$97In Stock
25 mg$198In Stock
50 mg$358In Stock
100 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$58In Stock
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Purity:98.21%
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Product Introduction

Bioactivity
Description
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
AliasNF1819, NF 1819
Chemical Properties
Molecular Weight463.46
FormulaC24H22FN5O4
Cas No.1881244-28-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (118.67 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1577 mL10.7884 mL21.5768 mL107.8842 mL
5 mM0.4315 mL2.1577 mL4.3154 mL21.5768 mL
10 mM0.2158 mL1.0788 mL2.1577 mL10.7884 mL
20 mM0.1079 mL0.5394 mL1.0788 mL5.3942 mL
50 mM0.0432 mL0.2158 mL0.4315 mL2.1577 mL
100 mM0.0216 mL0.1079 mL0.2158 mL1.0788 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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