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NSC697923

Catalog No. T6611 CAS 343351-67-7

Synonyms: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.

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NSC697923, CAS 343351-67-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 122.00
50 mg	In stock	$ 182.00
100 mg	In stock	$ 272.00
500 mg	In stock	$ 673.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.69%

Purity: 99.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.
In vitro	NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines. NSC697923 (3 μM; 2 hours) can also induce apoptosis in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 induces apoptosis in p53 wild-type NB cell lines by promoting p53 nuclear translocation and activation[1].
In vivo	NSC697923 (5 mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts[1].

Synonyms	2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
Molecular Weight	267.26
Formula	C11H9NO5S
CAS No.	343351-67-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 6.7 mg/mL (25 mM)), Heating is recommended.

DMSO: 180 mg/mL (673.5 mM), Sonification is recommended.

References and Literature

1. Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5(2):e1079. Published 2014 Feb 20. 2. Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10(7):1718-1728.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library Ubiquitination Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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SZL P1-41 Hinokiflavone Cbl-b-IN-9 Indole-3-carbinol Smurf1-IN-1 ML-792 PYZD-4409 N106

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NSC697923 343351-67-7 Ubiquitination E1/E2/E3 Enzyme NSC 697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran NSC-697923 inhibitor inhibit

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