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Navtemadlin

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Purity:98.86%

ee:100%

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COA CSFC HNMR HPLC LCMS

Navtemadlin

Catalog No. TQ0127Cas No. 1352066-68-2

Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.

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Pack Size	Price	Availability
1 mg	$67	In Stock
2 mg	$95	In Stock
5 mg	$147	In Stock
10 mg	$228	In Stock
25 mg	$463	In Stock
50 mg	$683	In Stock
100 mg	$973	In Stock

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Product Introduction

Bioactivity

Description	Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
In vitro	AMG 232 (10 μM) induces p53 signaling and inhibits tumor cell proliferation in three p53 wild-type tumor cell lines [1].
In vivo	AMG 232 (10, 25, 75 mg/kg, once daily, p.o.) activates p53 pathway activity in vivo and potently inhibits the growth of tumor xenografts in mice. It also blocks DNA synthesis and induces apoptosis in vivo[1]. AMG 232 causes a dose-dependent tumor growth inhibition with an ED50 of 16 mg/kg [2].
Cell Research	Cell Line: SJSA-1, HCT116, ACHN, NCI-H460, MOLM-13, RKO, MCF7, 22RV1, HT-29, PC-3, NCI-H82, NCI-SNU1, MG-63, NCI-H2452, SW982, C32, SK-HEP-1, A375, RT4, RPMI2650, MDA-MB-134-VI, NCI-H2347, and A427 cells. Concentration: 0-10 μM [1]. Incubation Time: 72 hours.
Animal Research	Animal Model: Female athymic nude mice (n=10) based cancer models. Dosage: 10, 25, 75 mg/kg. Administration: Once daily by oral gavage [1].
Alias	AMG232, CS-1300

Chemical Properties

Molecular Weight	568.55
Formula	C28H35Cl2NO5S
Cas No.	1352066-68-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: Insoluble

DMSO: 50 mg/mL (87.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7589 mL	8.7943 mL	17.5886 mL	87.9430 mL
5 mM	0.3518 mL	1.7589 mL	3.5177 mL	17.5886 mL
10 mM	0.1759 mL	0.8794 mL	1.7589 mL	8.7943 mL
20 mM	0.0879 mL	0.4397 mL	0.8794 mL	4.3972 mL
50 mM	0.0352 mL	0.1759 mL	0.3518 mL	1.7589 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc