store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 413.00 | |
10 mg | In stock | $ 663.00 | |
25 mg | In stock | $ 1,330.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 | |
500 mg | In stock | $ 4,900.00 |
Description | PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers. |
Targets&IC50 | PARP1:8.22 (pIC50), PI3Kγ:6.08 (pIC50), PI3Kα:8.25 (pIC50), PARP2:8.44 (pIC50), PI3Kβ:6.54 (pIC50), PI3Kδ:8.13 (pIC50) |
In vitro | PARP/PI3K-IN-1 (1 μM; 72 h) decreased the levels of self-phosphorylation of AKT and S6, while increasing the phosphorylation levels of ERK following treatment, indicating the inhibition of the PI3K pathway and activation of the ERK pathway by PARP/PI3K-IN-1, resulting in significantly increased apoptosis.[1]. In BRCA-deficient cells, PARP/PI3K-IN-1 not only exhibits significant inhibitory activity against HCC1937 and HCT116, but also demonstrates anti-proliferative activity against MDA-MB-231 and MDA-MB-468 [1]. |
In vivo | PARP/PI3K-IN-1 (IP; 50 mg/kg; treatment for 34 days) significantly inhibits tumor growth[1]. |
Molecular Weight | 660.62 |
Formula | C33H28F4N8O3 |
CAS No. | 2337386-47-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (121.10 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PARP/PI3K-IN-1 2337386-47-5 Chromatin/Epigenetic DNA Damage/DNA Repair PI3K/Akt/mTOR signaling PI3K PARP PARP/PI3KIN1 PARP/PI-3K-IN-1 PARP/PI3K IN 1 inhibitor inhibit