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PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $51 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $197 | In Stock | |
25 mg | $333 | In Stock | |
50 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $133 | In Stock |
Description | PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia. |
Targets&IC50 | GlyT1:11.6 nM(Ki) |
In vivo | PF-03463275 (1-10 mg/kg; s.c.; Male Sprague-Dawley rats) induces a dose-dependent reduction in the amplitude of oscillatory potentials (OPs) elicited from dark-adapted rats.[2] |
Alias | PF-3463275 |
Molecular Weight | 376.86 |
Formula | C19H22ClFN4O |
Cas No. | 1173239-39-8 |
Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (79.61 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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