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PF-03463275

Catalog No. T61564Cas No. 1173239-39-8
Alias PF-3463275

PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.

PF-03463275

PF-03463275

Purity: 99.86%
Catalog No. T61564Alias PF-3463275Cas No. 1173239-39-8
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$333In Stock
50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$133In Stock
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Purity:99.86%
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Product Introduction

Bioactivity
Description
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.
Targets&IC50
GlyT1:11.6 nM(Ki)
In vivo
PF-03463275 (1-10 mg/kg; s.c.; Male Sprague-Dawley rats) induces a dose-dependent reduction in the amplitude of oscillatory potentials (OPs) elicited from dark-adapted rats.[2]
AliasPF-3463275
Chemical Properties
Molecular Weight376.86
FormulaC19H22ClFN4O
Cas No.1173239-39-8
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (79.61 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6535 mL13.2675 mL26.5351 mL132.6753 mL
5 mM0.5307 mL2.6535 mL5.3070 mL26.5351 mL
10 mM0.2654 mL1.3268 mL2.6535 mL13.2675 mL
20 mM0.1327 mL0.6634 mL1.3268 mL6.6338 mL
50 mM0.0531 mL0.2654 mL0.5307 mL2.6535 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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