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PF429242 dihydrochloride

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Purity:98.67%

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COA HNMR HPLC

PF429242 dihydrochloride

Catalog No. T12437Cas No. 2248666-66-0

PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM).

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Pack Size	Price	Availability
1 mg	$36	In Stock
2 mg	$52	In Stock
5 mg	$85	In Stock
10 mg	$148	In Stock
25 mg	$297	In Stock
50 mg	$545	In Stock
100 mg	$785	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock

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Product Introduction

Bioactivity

Description	PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
In vitro	10 μM PF-429242 down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC50 of 0.5 μM[1]. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells[2]. PF-429242 has potent antiviral against LCMV and LASV [3].
In vivo	PF-429242 inhibits the expression of hepatic SREBP target genes, and the hepatic rates of cholesterol and fatty acid synthesis are reduced In mice[1].

Chemical Properties

Molecular Weight	482.49
Formula	C25H37Cl2N3O2
Cas No.	2248666-66-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (103.63 mM)

DMSO: 83.3 mg/mL (165.81 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0726 mL	10.3629 mL	20.7258 mL	103.6291 mL
5 mM	0.4145 mL	2.0726 mL	4.1452 mL	20.7258 mL
10 mM	0.2073 mL	1.0363 mL	2.0726 mL	10.3629 mL
20 mM	0.1036 mL	0.5181 mL	1.0363 mL	5.1815 mL
50 mM	0.0415 mL	0.2073 mL	0.4145 mL	2.0726 mL
100 mM	0.0207 mL	0.1036 mL	0.2073 mL	1.0363 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc