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Palmitic acid

Catalog No. T2908   CAS 57-10-3
Synonyms: Hexadecoic acid, hexadecanoic acid, Cetylic acid

Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms. Palmitic acid has antitumor activity.

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Palmitic acid Chemical Structure
Palmitic acid, CAS 57-10-3
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5 g In stock $ 48.00
10 g In stock $ 65.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 99.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms. Palmitic acid has antitumor activity.
In vitro METHODS: Mouse microglia BV2 were treated with Palmitic acid (25-200 nM) for 6-48 h, and cell viability was measured by MTT.
RESULTS: Palmitic acid had concentration- and time-dependent inhibitory effects on microglia viability. [1]
METHODS: Monocyte-derived dendritic cells MoDC were treated with Palmitic acid (150 μM) for 12 h. The expression of DC co-stimulatory factors was measured by Flow Cytometry.
RESULTS: Palmitic acid induced the expression of CD86 and CD83, indicating that the activation and maturation of MoDC were induced simultaneously. [2]
In vivo METHODS: To investigate the effects on adverse biological behaviors in mice, Palmitic acid (0.3-30 μmol/mouse in castor oil) was administered as a single intraperitoneal injection to C57BL/6J mice, and biological behaviors were analyzed 2-24 h later.
RESULTS: In a dose-dependent manner, Palmitic acid rapidly reduced locomotor activity in mice through a mechanism dependent on fatty acid chain length. 24 h after Palmitic acid administration, mice exhibited anxiety-like behaviors, whereas there was no impairment of locomotion, food intake, depression-like behaviors, or spatial memory. [3]
METHODS: To investigate the effects on myocardial injury, Palmitic acid (5 mM in 500 μL solution) was injected intravenously into the tail of wild-type C57BL/6 (B6) and Md2-/- (KO) mice once a day for seven days.
RESULTS: Palmitic acid induced myocardial inflammatory injury via TLR4 accessory protein MD2 and protected Md2 knockout mice from myocardial injury induced by Palmitic acid and high-fat diet. [4]
Kinase Assay As sources of PLA2, human recombinant sPLA2 (type IIA) is purified from CHO cells transfected with the PLA2 gene and rabbit recombinant platelet cPLA2 is obtained through its expression in baculovirus. The standard reaction mixture (200 μL) contained 100 mM Tris-HCl buffer (pH 9.0) with 6 mM CaCl2 and 20 nmol 1-acyl-[1-14C]-arachidonyl-sn-glycerophosphoethanolamine (2000 cpm/nmol) in the presence or absence of Tanshinone I. The reaction is started by adding 50 ng purified sPLA2 or cPLA2. After 20 min at 37°C, the free fatty acid generated is analysed. Under these standard conditions, the reaction mixture in the absence of Tanshinone I released approximately 10% of free fatty acid from the phospholipid substrate added[1].
Source
Synonyms Hexadecoic acid, hexadecanoic acid, Cetylic acid
Molecular Weight 256.42
Formula C16H32O2
CAS No. 57-10-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.56 mg/mL (10 mM)

Ethanol: 27.78 mg/mL (108.33 mM), Sonification is recommended

TargetMolReferences and Literature

1. Urso CJ, et al. Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids. Int J Mol Sci. 2021 Aug 23;22(16):9093. 2. Nicholas DA, et al. Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β. PLoS One. 2017 May 2;12(5):e0176793. 3. Moon ML, et al. The saturated fatty acid, palmitic acid, induces anxiety-like behavior in mice. Metabolism. 2014 Sep;63(9):1131-40. 4. Wang Y, et al. Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2. Nat Commun. 2017 Jan 3;8:13997.

TargetMolCitations

1. Fu C N, Wei H, Gao W S, et al. Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats. Aging (Albany NY). 2021, 13(14): 18606. 2. Fang X X, Wei P, Zhao K, et al.Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.Journal of Cell Biology.2024, 223(4).

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Human Endogenous Metabolite Library Miao medicine Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Microbial Natural Product Library Antiparasitic Natural Product Library Marine Natural Product Library Inactive Ingredient Library

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Keywords

Palmitic acid 57-10-3 Cytoskeletal Signaling Metabolism HSP Endogenous Metabolite Hexadecoic acid Inhibitor hexadecanoic acid Cetylic acid inhibit Heat shock proteins inhibitor

 

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