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Ramoplanin

Catalog No. TP2152 CAS 76168-82-6

Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic with activity against gram-positive bacteria. It is existed in the Actinoplanes spp.

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Ramoplanin, CAS 76168-82-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic with activity against gram-positive bacteria. It is existed in the Actinoplanes spp.
In vitro	Ramoplanin blocks peptidoglycan synthesis via lipid II, then exerts bactericidal activity against gram-positive aerobic and anaerobic bacteria [1].
In vivo	During treatment, Ramoplanin (100, 500 μg/ml; p.o.; for 8 days) suppresses vancomycin-resistant Enterococcus (VRE) to undetectable level [1].

Molecular Weight	N/A
CAS No.	76168-82-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Stiefel U, et al. Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice. Antimicrob Agents Chemother. 2004 Jun;48(6):2144-8. 2. Cheng M, et al. Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus. Antimicrob Agents Chemother. 2014 Nov;58(11):6819-27.

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Keywords

Ramoplanin 76168-82-6 微生物学 Antibacterial Inhibitor inhibitor inhibit

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