Shopping Cart
- Remove All
Your shopping cart is currently empty
Ranirestat
Catalog No. T16723Cas No. 147254-64-6
Alias SX-3030, SX3030, AS-3201, AS3201, AS 3201
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
Ranirestat
Catalog No. T16723Alias SX-3030, SX3030, AS-3201, AS3201, AS 3201Cas No. 147254-64-6
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $399 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Ranirestat"
Epalrestat
Cited
ONO2235
T145882159-09-9
Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy and good glycemic control.
- $30
Size
QTY
Cited2-Chloro-1-(4-fluorobenzyl)benzimidazole
T747884946-20-3
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2).
- $31
Size
QTY
Dutasteride Cited
GI 198745, GG 745, Avodart
T1499164656-23-9
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
- $32
Size
QTY
CitedIsoliquiritigenin Cited
Isoliquiritigen, ISL, GU17
T0725961-29-5
Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.
- $50
Size
QTY
CitedLidorestat
IDD-676
T15756245116-90-9In house
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
- $40
Size
QTY
Alpha-Estradiol
Epiestrol, Epiestradiol, Alfatradiol, 17α-Estradiol
T337857-91-0
Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.
- $50
Size
QTY
Finasteride
MK-906
T048898319-26-7
Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.
- $35
Size
QTY
MK 0434
MK-434, MK434, MK-0434, MK0434, MK 434
T33414134067-56-4In house
MK 0434 is an orally active steroidal 5 alpha-reductase inhibitor.
- $293
Size
QTY
Alconil
Al-1567, Al1567, Al 1567
T2984497677-19-5In house
Alconil (Al 1567) is an aldose reductase inhibitor that may be used to study chronic obstructive pulmonary disease (COPD) and diabetes.
- $293
Size
QTY
Epristeride
SKF105657, ONO-9302
T15239119169-78-7In house
Epristeride (ONO-9302) is an orally active, selective and non-competitive steroidal 5-α-reductase isoform 2 inhibitor that inhibits SR isoform 2.Episteride reduces prostate size and improves symptoms in men with BPH.Episteride induces atrophy and apoptosis of the ventral prostate in rats.
- $100
Size
QTY
D-Methionine sulfoxide
T1926521056-56-4In house
D-Methionine sulfoxide inhibits peptide methionine sulfoxide reductase and can be used to inhibit ochre mites.D-Methionine sulfoxide can be added to chicken feed to promote growth.
- $41
Size
QTY
Tolrestat
AY-27773
T1711482964-04-3In house
Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).
- $40
Size
QTY
Select Batch
Purity:96.10%
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy. |
| Targets&IC50 | Recombinant humanaldose reductase:0.38 nM （Ki）, Aldose reductase (rat lens):11 nM, Recombinant humanaldose reductase:15 nM |
| In vitro | Ranirestat concentration-dependently inhibits sorbitol accumulation in rat erythrocytes and sciatic nerves incubated in a high concentration (500 mg/dl) of glucose[1]. |
| In vivo | In approximately 12-week-old male STD-Wistar rats (260-290 g) injected with Streptozotocin (STZ), Ranirestat (0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg; oral administration, once daily, for 3 weeks) dose-dependently decreased the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose levels[1]. |
| Alias | SX-3030, SX3030, AS-3201, AS3201, AS 3201 |
| Molecular Weight | 420.19 |
| Formula | C17H11BrFN3O4 |
| Cas No. | 147254-64-6 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (71.40 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Ranirestat | purchase Ranirestat | Ranirestat cost | order Ranirestat | Ranirestat chemical structure | Ranirestat in vivo | Ranirestat in vitro | Ranirestat formula | Ranirestat molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.