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Ranirestat
🥰Excellent
Catalog No. T16723Cas No. 147254-64-6
Alias SX-3030, SX3030, AS-3201, AS3201, AS 3201
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
Ranirestat
🥰Excellent
Purity: 96.10%
Catalog No. T16723Alias SX-3030, SX3030, AS-3201, AS3201, AS 3201Cas No. 147254-64-6
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | 379 € | In Stock |
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Purity:96.10%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy. |
| Targets&IC50 | Recombinant humanaldose reductase:15 nM, Recombinant humanaldose reductase:0.38 nM （Ki）, Aldose reductase (rat lens):11 nM |
| In vitro | Ranirestat concentration-dependently inhibits sorbitol accumulation in rat erythrocytes and sciatic nerves incubated in a high concentration (500 mg/dl) of glucose[1]. |
| In vivo | In approximately 12-week-old male STD-Wistar rats (260-290 g) injected with Streptozotocin (STZ), Ranirestat (0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg; oral administration, once daily, for 3 weeks) dose-dependently decreased the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose levels[1]. |
| Alias | SX-3030, SX3030, AS-3201, AS3201, AS 3201 |
| Molecular Weight | 420.19 |
| Formula | C17H11BrFN3O4 |
| Cas No. | 147254-64-6 |
| Smiles | Fc1cc(Br)ccc1CN1C(=O)c2cccn2[C@@]2(CC(=O)NC2=O)C1=O |
| Relative Density. | 1.83 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (71.40 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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