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Regorafénib N-oxyde (M2)

Catalog No. T10157 CAS 835621-11-9

Synonyms: 瑞戈非尼杂质 13

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).

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Regorafénib N-oxyde (M2), CAS 835621-11-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).
Targets&IC50	VEGFR1:13nM , RET:22nM , VEGFR2:4.2nM , VEGFR3:46nM , Raf-1:2.5 nM , PDGFRβ:1.5nM , Kit:7nM

Synonyms	瑞戈非尼杂质 13
Molecular Weight	498.82
Formula	C21H15ClF4N4O4
CAS No.	835621-11-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Drug Metabolite/Impurity Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library Epigenetics Compound Library Angiogenesis related Compound Library Anti-Fibrosis Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

SU14813 maleate Imatinib impurities3 Dovitinib Dilactic Acid Dovitinib (TKI258) Lactate PD180970 c-Kit-IN-5-1 PLX647 Agerafenib hydrochloride

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Keywords

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