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Resorcinolnaphthalein

Catalog No. T13865Cas No. 41307-63-5

Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).

Resorcinolnaphthalein

Resorcinolnaphthalein

Purity: 99.25%
Catalog No. T13865Cas No. 41307-63-5
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).
Pack SizePriceAvailabilityQuantity
10 mg$39In Stock
25 mg$64In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Purity:99.25%
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Product Introduction

Bioactivity
Description
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).
Targets&IC50
ACE2:(EC50)19.5 μM
In vitro
ACE2 activity in a dose-dependent manner enhanced by Resorcinolnaphthalein (100 μM) and XNT (EC50 values of 19.5 μM and 20.1 μM, respectively).ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology.
In vivo
resorcinolnaphthalein enhanced ACE2 activity in a dose-dependent manner. Acute in vivo administration of the xanthenone resulted in a dose-dependent transient and robust decrease in blood pressure (at 10 mg/kg, spontaneously hypertensive rats decreased 71+/-9 mm Hg and Wistar-Kyoto rats decreased 21+/-8 mm Hg; P<0.05). Chronic infusion of the xanthenone (120 microg/day) resulted in a modest decrease in the spontaneously hypertensive rat blood pressure (17 mm Hg; 2-way ANOVA; P<0.05), whereas it had no effect in Wistar-Kyoto rats. Strikingly, the decrease in blood pressure was also associated with improvements in cardiac function and reversal of myocardial, perivascular, and renal fibrosis in the spontaneously hypertensive rats[1].
Chemical Properties
Molecular Weight382.36
FormulaC24H14O5
Cas No.41307-63-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 120 mg/mL (313.84 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6153 mL13.0767 mL26.1534 mL130.7668 mL
5 mM0.5231 mL2.6153 mL5.2307 mL26.1534 mL
10 mM0.2615 mL1.3077 mL2.6153 mL13.0767 mL
20 mM0.1308 mL0.6538 mL1.3077 mL6.5383 mL
50 mM0.0523 mL0.2615 mL0.5231 mL2.6153 mL
100 mM0.0262 mL0.1308 mL0.2615 mL1.3077 mL

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