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Ribocil
Catalog No. T13869LCas No. 1381289-58-2
Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches, strongly inhibiting GFP expression with a 50% effective concentration (EC50: 0.3 μM).
Ribocil
Catalog No. T13869LCas No. 1381289-58-2
Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches, strongly inhibiting GFP expression with a 50% effective concentration (EC50: 0.3 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $51 | In Stock | |
| 2 mg | $72 | In Stock | |
| 5 mg | $130 | In Stock | |
| 10 mg | $217 | In Stock | |
| 25 mg | $363 | In Stock | |
| 50 mg | $539 | In Stock | |
| 100 mg | $778 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $117 | In Stock |
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Purity:99.71%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches, strongly inhibiting GFP expression with a 50% effective concentration (EC50: 0.3 μM). |
| In vitro | Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B shows superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM) [1] |
| Molecular Weight | 382.48 |
| Formula | C19H22N6OS |
| Cas No. | 1381289-58-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 24.8 mg/mL (64.84 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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