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ST034307

Catalog No. T16938 CAS 133406-29-8

ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).

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ST034307, CAS 133406-29-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 248.00
50 mg	In stock	$ 426.00
100 mg	In stock	$ 632.00
500 mg	In stock	$ 1,350.00
1 mL * 10 mM (in DMSO)	In stock	$ 81.00

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Purity: 99.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
Targets&IC50	AC type I:2.3 μM
In vitro	ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1].
In vivo	ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice [1].

Molecular Weight	297.95
Formula	C10H4Cl4O2
CAS No.	133406-29-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (167.81 mM), Sonication and heating are recommended.

References and Literature

1. Brust TF, et al. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci Signal. 2017 Feb 21;10(467).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Neuronal Signaling Compound Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ST034307 133406-29-8 Neuroscience Adenylyl cyclase Adenylate Cyclase Inhibitor ST-034307 inhibit ST 034307 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.