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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $32 | In Stock | |
2 mg | $45 | In Stock | |
5 mg | $74 | In Stock | |
10 mg | $117 | In Stock | |
25 mg | $248 | In Stock | |
50 mg | $426 | In Stock | |
100 mg | $632 | In Stock | |
500 mg | $1,350 | In Stock | |
1 mL x 10 mM (in DMSO) | $81 | In Stock |
Description | ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM). |
In vitro | ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1]. |
In vivo | ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice [1]. |
Molecular Weight | 297.95 |
Formula | C10H4Cl4O2 |
Cas No. | 133406-29-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (167.81 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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