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STAT5-IN-1
STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
Catalog No. T4216Cas No. 285986-31-4
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Purity:99.92%
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STAT5-IN-1
Catalog No. T4216Alias STAT5 InhibitorCas No. 285986-31-4
STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $47 | In Stock | |
| 10 mg | $86 | In Stock | |
| 25 mg | $183 | In Stock | |
| 50 mg | $322 | In Stock | |
| 100 mg | $547 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $47 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain. |
| Targets&IC50 | STAT5:47 μM |
| In vitro | The chemical compound STAT5-IN-1 serves as an inhibitor of Signal Transducer and Activator of Transcription 5 (STAT5), a protein crucial for cell growth and differentiation. By attaching to the SH2 domain of STAT5, it selectively impedes its activity. While it also affects STAT3, STAT1, and the Lck tyrosine kinase, this inhibition is significantly less pronounced (IC50 > 500 μM). Additionally, STAT5-IN-1 effectively prevents the interaction between STAT5 and DNA within K562 nuclear extracts. Notably, modifying the chromone ring's C6 hydrogen to an ethyl group in STAT5-IN-1 does not diminish its efficacy against STAT5β; however, it eradicates its selectivity towards other STAT family members. |
| Alias | STAT5 Inhibitor |
| Molecular Weight | 293.28 |
| Formula | C16H11N3O3 |
| Cas No. | 285986-31-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (170.49 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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