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Sulforaphane

Catalog No. TQ0207 CAS 4478-93-7

Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.

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Sulforaphane, CAS 4478-93-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 47.00
25 mg	In stock	$ 109.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 289.00
500 mg	In stock	$ 713.00

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Purity: 99.79%

Purity: 98.29%

Purity: 95%

Biological Description

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Storage & Solubility Information

Description	Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.
In vitro	Sulforaphane triggers a dose-dependent cell cycle arrest, leading to cell death, and this effect is associated with elevated levels of cyclins A and B1. It promotes apoptosis to cause cell death and blocks the resumption of growth, reducing the survival of quiescent colon carcinoma cells (HT29), while exhibiting less toxicity towards differentiated CaCo2 cells [1]. Additionally, sulforaphane pre-treatment in H9c2 rat myoblasts lowers the number of apoptotic cells and the presence of pro-apoptotic proteins, alongside mitigating the doxorubicin-induced rise in mitochondrial membrane potential. It also enhances mRNA and protein levels of heme oxygenase-1, thereby decreasing reactive oxygen species in mitochondria triggered by doxorubicin [2].
In vivo	Administration of sulforaphane reduces the incidence, multiplicity, and weights and delays the development of the mammary tumors evoked by a single dose of DMBA in female SD rats [3].
Cell Research	HT29 cells are seeded at low density (5×10^4 cells/mL) in 35- or 120-mm diameter Primaria dishes in standard medium containing 5% FCS. One day after seeding, the medium is changed, and HT29 cells are treated with sulforaphane (0-30 μM). An equivalent amount of the solvent (ethanol) is added to control cells (0.2% final concentration). The drug effect on cellular viability is evaluated using the MTT assay [1].
Animal Research	At age 47, 48, 49, 50, and 51 days, each animal receives by gavage either 0.5 mL of Emulphor EL-620 alone or the specified doses (75, 100, or 150 μM daily) of sulforaphane or compound 2, 3, or 4 in 0.5 mL of Emulphor EL-620. On day 50, 3 hr after administration of the vehicle or protector, all rats also receive an intragastric instillation of 8.0 mg of DMBA dissolved in 1.0 mL of sesame oil. This dose of DMBA is selected to produce a substantial tumor incidence, but not one so high as to overwhelm a potential chemoprotective effect. The animals are examined once weekly for the appearance and location of palpable tumors. At age 202 days, i.e., 152 days after carcinogen administration, all animals are euthanized with ether and weighed. The tumors are separated from the fat and connective tissue by dissection weighed and fixed in buffered 10% formalin. All tumors are identified microscopically by examination of stained sections [3].
Source	Natural Products > Brassicaceae > Brassica

Molecular Weight	177.29
Formula	C6H11NOS2
CAS No.	4478-93-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (338.43 mM)

References and Literature

1. Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000 Mar 1;60(5):1426-33. 2. Li B, et al. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015 Jul;36(1):53-64. 3. Zhang Y, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornylisothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Obesity Compound Library Natural Product Library Autophagy Compound Library Human Metabolite Library Histone Modification Compound Library Transcription Factor-Targeted Compound Library

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Keywords

Sulforaphane 4478-93-7 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Immunology/Inflammation Nrf2 HDAC Keap1-Nrf2 inhibit Inhibitor Histone deacetylases inhibitor

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