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T025

Catalog No. T13058   CAS 2407433-00-3

T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 30-300 nM in hematological and solid cancer cell lines. T025 can be used in studies about MYC-driven diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
T025 Chemical Structure
T025, CAS 2407433-00-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 146.00
5 mg In stock $ 372.00
10 mg In stock $ 556.00
25 mg In stock $ 896.00
50 mg In stock $ 1,220.00
100 mg In stock $ 1,650.00
500 mg In stock $ 3,290.00
1 mL * 10 mM (in DMSO) In stock $ 397.00
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Purity: 98.08%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 30-300 nM in hematological and solid cancer cell lines. T025 can be used in studies about MYC-driven diseases.
Targets&IC50 CLK2:0.096 nM (kd), CLK4:0.61 nM (kd), CLK3:6.5 nM (kd), CLK1:4.8 nM (kd)
In vitro In MDA-MB-468 cells, T025 (1-1000 nM) dose-dependently suppresses cell growth and reduces pCLK2 and CLK2 phosphorylation levels[1].
In vivo In Balb/c nude mice, gavage administration of T025 (50 mg/kg) suppresses tumor growth and < 10% nadir body weight loss. Gavage administration of T025 (50 mg/kg) inhibits the CLK-dependent phosphorylation and decreases the RPS6KB1 exon 7 and BCLAF1 exon 11 percentage splice-in values[1].
Molecular Weight 382.42
Formula C21H18N8
CAS No. 2407433-00-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.4 mg/mL (19.4 mM), sonification is recommended.

TargetMolReferences and Literature

1. Iwai K, et al. Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability. EMBO Mol Med. 2018 Jun;10(6). pii: e8289.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compounds Library Max Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library

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BRD7389 SEL120-34A HCl CLK1-IN-3 THZ1-R BRD6989 ALSTERPAULLONE AS2863619 free base THZ1

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Keywords

T025 2407433-00-3 Cell Cycle/Checkpoint CDK T 025 T-025 inhibitor inhibit

 

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