Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 287.00 | |
10 mg | In stock | $ 428.00 | |
25 mg | In stock | $ 686.00 | |
50 mg | In stock | $ 969.00 | |
100 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 2,620.00 |
Description | TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively). |
In vitro | TC-I 2014 effectively inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8 (IC50: 0.413 and 1 nM, respectively) [1]. |
In vivo | TC-I 2014 (10 mg/kg, Orally once) fully avoids icilin-induced WDS [1]. |
Molecular Weight | 467.41 |
Formula | C23H19F6N3O |
CAS No. | 1221349-53-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (481.4 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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TC-I 2014 1221349-53-6 Membrane transporter/Ion channel TRP/TRPV Channel TCI 2014 TC-I-2014 TC-I2014 TC I 2014 inhibitor inhibit