store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
2 mg | In stock | $ 169.00 | |
5 mg | In stock | $ 287.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 753.00 | |
50 mg | In stock | $ 1,060.00 | |
100 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 379.00 |
Description | TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs. |
In vitro | TCH-165, resulting in an increase in 20S levels.?The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs, including α-synuclein, tau, ornithine decarboxylase, and c-Fos, but not structured proteins.?Clearance of ubiquitinated protein was largely maintained by single capped proteasome complexes (19S-20S), but accumulation occurs when all 19S capped proteasome complexes are depleted[1]. |
Molecular Weight | 595.73 |
Formula | C39H37N3O3 |
CAS No. | 1446350-60-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (83.93 mM)
You can also refer to dose conversion for different animals. More
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TCH-165 1446350-60-2 Proteases/Proteasome Ubiquitination Proteasome tau trypsin-like 20S IDPs chymotrypsin-like degradation α-syn inhibit TCH 165 caspase-like TCH165 assembly Inhibitor inhibitor