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TRC051384

Catalog No. T3527 CAS 867164-40-7

Synonyms: TRC 051384

TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated molecular chaperone and anti-inflammatory activity, and enhances Hsp72 expression in neurons and glial cells.

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TRC051384, CAS 867164-40-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 45.00
2 mg	In stock	$ 64.00
5 mg	In stock	$ 101.00
10 mg	In stock	$ 182.00
25 mg	In stock	$ 377.00
50 mg	In stock	$ 552.00
100 mg	In stock	$ 787.00
200 mg	In stock	$ 1,070.00
1 mL * 10 mM (in DMSO)	In stock	$ 110.00

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Purity: 92.66%

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Description	TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated molecular chaperone and anti-inflammatory activity, and enhances Hsp72 expression in neurons and glial cells.
In vitro	TRC051384 significantly enhances HSP70B mRNA expression hundreds of times in both HeLa cells and rat primary mixed neurons in a dose-dependent fashion. Additionally, it markedly boosts HSF1 transcriptional activity and luciferase recovery upon treatment, following a dose-responsive pattern. Furthermore, TRC051384 demonstrates substantial inhibitory effects on LPS-induced TNF-α expression in the differentiated THP-1 cell line, achieving 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM [1].
In vivo	Administering TRC051384 significantly diminishes stroke-related neuronal damage and disability in a rat model of transient ischemic stroke, achieving an 87% reduction in the area of the penumbra recruited to infarct and a 25% reduction in brain edema, even when treatment commences 8 hours after ischemia onset. Additionally, initiating TRC051384 treatment 4 hours post-ischemia onset notably enhances survival rates, with a 50% improvement by day 2 and a 67.3% increase by day 7. The mechanism underlying TRC051384's efficacy involves the induction of HSP70 through HSF1 activation, which amplifies chaperone and anti-inflammatory activities[1].
Cell Research	HeLa cell transiently co-transfected with heat shock elements-luciferase reporter and normalization vector, β-galactosidase are treated with vehicle or TRC051384 (12.5 and 25 μM) for 4 hours. Cell lysates are then prepared and analyzed for luciferase and β-galactosidase activity[1].

Synonyms	TRC 051384
Molecular Weight	465.54
Formula	C25H31N5O4
CAS No.	867164-40-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL

References and Literature

1. Mohanan A, et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9.

Related compound libraries

This product is contained In the following compound libraries：

Endoplasmic Reticulum Stress Compound Library Cytoskeletal Signaling Pathway Compound Library NO PAINS Compound Library Covalent Inhibitor Library Anti-Fibrosis Compound Library Target-Focused Phenotypic Screening Library Immunology/Inflammation Compound Library

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Keywords

TRC051384 867164-40-7 Cytoskeletal Signaling Metabolism HSP TRC-051384 TRC 051384 Heat shock proteins Inhibitor inhibit inhibitor

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