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Taxifolin

Catalog No. T1738 CAS 480-18-2

Synonyms: (+)-Taxifolin, Dihydroquercetin, (+)-Dihydroquercetin

Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.

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Taxifolin, CAS 480-18-2

Pack Size	Availability	Price/USD
50 mg	In stock	$ 46.00
100 mg	In stock	$ 73.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.9%

Purity: 98.21%

Purity: 94.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
Targets&IC50	Collagenase:193.3 μM
In vivo	Taxifolin may be easily metabolized and that its metabolites are the prevalent form in vivo, although limited information is available on metabolism of Taxifolin in vivo[5]. Metabolites with the same fragment pattern may have the same pharmacophore. Thus these metabolites may exert the same pharmacological effects as taxifolin through an additive effect on the same drug targets. This observation indicates that taxifolin is bioactive not only in the parent form, but also through its metabolites.
Source	Natural Products > Taxaceae > Taxus

Synonyms	(+)-Taxifolin, Dihydroquercetin, (+)-Dihydroquercetin
Molecular Weight	304.25
Formula	C15H12O7
CAS No.	480-18-2

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56 mg/mL (184.1 mM)

Ethanol: 56 mg/mL (184.1 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Makena PS, et al. Environ Mol Mutagen, 2009, 50(6), 451-459. 2. Lee SB, et al. Biol Pharm Bull, 2007, 30(6), 1074-1079. 3. Luo H, et al. Nutr Cancer, 2008, 60(6), 800-809. 4. Sharad Verma, et al. Journal of Applied Pharmaceutical Science. 2012, 2 (1): 41-46. 5. Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209. 6. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11). pii: E1586. 7. Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation[J]. Molecules. 2021, 26(4): 784.

Citations

1. Abderrezag N, Montenegro Z J S, Louaer O, et al. One-step sustainable extraction of Silymarin compounds of wild Algerian milk thistle (Silybum marianum) seeds using Gas Expanded Liquids. Journal of Chromatography A. 2022: 463147 2. Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation. Molecules. 2021 Feb 3;26(4):784. doi: 10.3390/molecules26040784. 3. Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477. 4. Tang X, Liu L, Li Y, et al.Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.Biomedicine & Pharmacotherapy.2023, 166: 115315. 5. Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477.

Related compound libraries

This product is contained In the following compound libraries：

Miao medicine Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Tobacco Monomer Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library Tyrosine Kinase Inhibitor Library HIF-1 Signaling Pathway Compound Library Polyphenolic Natural Product Library Natural Product Library

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Keywords

Taxifolin 480-18-2 Angiogenesis Apoptosis Autophagy GPCR/G Protein Neuroscience Proteases/Proteasome Tyrosine Kinase/Adaptors TNF VEGFR Tyrosinase Adrenergic Receptor (+)-Taxifolin antifibrotic antioxidant inhibit Inhibitor Dihydroquercetin (+)-Dihydroquercetin inhibitor

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