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Tenidap
🥰Excellent
Catalog No. T17036Cas No. 120210-48-2
Alias CP-66248
Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.
Tenidap
🥰Excellent
Purity: 99.42%
Catalog No. T17036Alias CP-66248Cas No. 120210-48-2
Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $109 | In Stock | |
| 25 mg | $235 | In Stock | |
| 50 mg | $392 | In Stock | |
| 100 mg | $683 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock |
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CitedSelect Batch
Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities. |
| Targets&IC50 | COX-1:0.03 μM, COX-2:1.2 μM |
| In vitro | The human astrocytoma cell line U373 MG was incubated with 0.1-100 µM tenidap for 30 min and then stimulated with 50 µM C6-ceramide for 24 h. Tenidap inhibited the dose-dependent ceramide-induced IL-6 protein synthesis in U373 human astrocytoma cells.[4] |
| In vivo | After sustained epilepsy (SE) induced by trichostatin in male Wistar rats, Tenidap was administered at 10 mg / kg daily for 10 days, 46.88 ± 10.70 neurons survived in the tenidap-SE group, and 37.75 ± 8.78 neurons survived in the tenidap-SE group, Tenidap significantly inhibited the hippocampal expression of COX-2 in the hippocampus, especially in the CA3 region.[3] |
| Alias | CP-66248 |
| Molecular Weight | 320.75 |
| Formula | C14H9ClN2O3S |
| Cas No. | 120210-48-2 |
| Smiles | NC(=O)N1C(=O)\C(=C(/O)c2cccs2)c2cc(Cl)ccc12 |
| Relative Density. | 1.648 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (62.35 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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