Home Tools
Log in
Cart

Terbinafine hydrochloride

Catalog No. T1411   CAS 78628-80-5
Synonyms: KWD 2019, Terbinafine HCl, TDT 067 hydrochloride

Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Terbinafine hydrochloride Chemical Structure
Terbinafine hydrochloride, CAS 78628-80-5
Pack Size Availability Price/USD Quantity
25 mg In stock $ 30.00
50 mg In stock $ 39.00
100 mg In stock $ 53.00
200 mg In stock $ 90.00
1 mL * 10 mM (in DMSO) In stock $ 57.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.89%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.
Targets&IC50 squalene epoxidase:30 nM(ki)
In vitro Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5]
In vivo Terbinafine is not only active after topical application but also very effective in experimental dermatophytoses following oral administration. In fungi-infected guinea pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[6].
Synonyms KWD 2019, Terbinafine HCl, TDT 067 hydrochloride
Molecular Weight 327.89
Formula C21H26ClN
CAS No. 78628-80-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.8 mg/mL (100 mM)

TargetMolReferences and Literature

1. Vickers AE, et al. Drug Metab Dispos, 1999, 27(9), 1029-1038. 2. Ryder NS, et al. Med Mycol, 2001, 39(1), 91-95. 3. Abdel-Rahman SM, et al. Drug Metab Dispos, 1999, 27(7), 770-775. 4. Garcia-Effron G, et al. J Antimicrob Chemother, 2004, 53(6), 1086-1089. 5. Ho PY, et al. Toxicol Appl Pharmacol, 2008, 229(1), 86-93.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Natural Product Library FDA-Approved Drug Library Anti-Bacterial Compound Library Selected Plant-Sourced Compound Library NO PAINS Compound Library Anti-Fungal Compound Library Antibiotics Library Natural Product Library for HTS Drug Repurposing Compound Library

Related Products

Related compounds with same targets
Sulconazole mononitrate Tetracycline hydrochloride Sanfetrinem Chloramphenicol succinate sodium Eperezolid Danofloxacin mesylate Cefixime Cefditoren pivoxil

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Terbinafine hydrochloride 78628-80-5 Microbiology/Virology Antibiotic Antifungal Antibacterial bacteria Fungal antibacterial activity TDT-067 infections Bacterial KWD-2019 TDT 067 Hydrochloride TDT-067 Hydrochloride TDT067 Hydrochloride Inhibitor TDT067 KWD2019 squalene epoxidase Candida Terbinafine Hydrochloride Terbinafine KWD 2019 Terbinafine HCl inhibit TDT 067 hydrochloride TDT 067 inhibitor

 

TargetMol