Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 30.00 | |
50 mg | In stock | $ 39.00 | |
100 mg | In stock | $ 53.00 | |
200 mg | In stock | $ 90.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes. |
Targets&IC50 | squalene epoxidase:30 nM(ki) |
In vitro | Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5] |
In vivo | Terbinafine is not only active after topical application but also very effective in experimental dermatophytoses following oral administration. In fungi-infected guinea pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[6]. |
Synonyms | KWD 2019, Terbinafine HCl, TDT 067 hydrochloride |
Molecular Weight | 327.89 |
Formula | C21H26ClN |
CAS No. | 78628-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.8 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Terbinafine hydrochloride 78628-80-5 Microbiology/Virology Antibiotic Antifungal Antibacterial bacteria Fungal antibacterial activity TDT-067 infections Bacterial KWD-2019 TDT 067 Hydrochloride TDT-067 Hydrochloride TDT067 Hydrochloride Inhibitor TDT067 KWD2019 squalene epoxidase Candida Terbinafine Hydrochloride Terbinafine KWD 2019 Terbinafine HCl inhibit TDT 067 hydrochloride TDT 067 inhibitor