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Thrombin (MW 37kDa)

Catalog No. T19580 CAS 9002-04-4

Synonyms: Thrombin

Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.

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Thrombin (MW 37kDa), CAS 9002-04-4

Pack Size	Availability	Price/USD	Quantity
1000 U	Inquiry	$ 139.00
2000 U	Inquiry	$ 232.00

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Potency: 2000U/mg

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.
In vitro	Low concentrations of thrombin and thrombin preconditioning yield the potential of rescuing cells and to induce survival of neurons and astrocytes exposed to various ischemic insults[1].
In vivo	Elevated thrombin activity was found in the brain slices from mice that were treated (in vitro and in vivo) with paraoxon. Increased levels of PAR-1 and pERK proteins and decreased prothrombin mRNA were found in the brains of paraoxon-treated mice. Furthermore, ex vivo and in vivo electrophysiological experiments showed that exposure to paraoxon causes elevated electrical activity in CA1 and CA3 regions of the hippocampus. Moreover, a specific PAR-1 antagonist (SCH79797) reduced this activity. Altogether, these results reveal the importance of thrombin and PAR-1 in paraoxon poisoning[2].

Synonyms	Thrombin
Molecular Weight	37kDa
CAS No.	9002-04-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Golderman V, et al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2018 Dec 4. 2. Krenzlin H, et al. The Importance of Thrombin in Cerebral Injury and Disease. Int J Mol Sci. 2016 Jan 11;17(1).

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Keywords

Thrombin (MW 37kDa) 9002-04-4 Proteases/Proteasome Thrombin Inhibitor inhibit inhibitor

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