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Trigonelline

🥰Excellent
Catalog No. T2887Cas No. 535-83-1
Alias Trigenolline

Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Trigonelline

Trigonelline

🥰Excellent
Purity: 99.54%
Catalog No. T2887Alias TrigenollineCas No. 535-83-1
Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
Pack SizePriceAvailabilityQuantity
5 mg$33In Stock
10 mg$55In Stock
25 mg$90In Stock
50 mg$128In Stock
100 mg$172In Stock
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Purity:99.54%
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Product Introduction

Bioactivity
Description
Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
In vitro
Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1].
In vivo
Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2].
AliasTrigenolline
Chemical Properties
Molecular Weight137.14
FormulaC7H7NO2
Cas No.535-83-1
SmilesC[n+]1cccc(c1)C([O-])=O
Relative Density.1.2528 g/cm3 (Estimated)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 7.5 mg/mL (54.69 mM), Sonication is recommended.
Ethanol: Insoluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM7.2918 mL36.4591 mL72.9182 mL364.5909 mL
5 mM1.4584 mL7.2918 mL14.5836 mL72.9182 mL
10 mM0.7292 mL3.6459 mL7.2918 mL36.4591 mL
20 mM0.3646 mL1.8230 mL3.6459 mL18.2295 mL
50 mM0.1458 mL0.7292 mL1.4584 mL7.2918 mL

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