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Tyloxapol

Catalog No. T0307   CAS 25301-02-4
Synonyms: Triton WR1339

Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.

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Tyloxapol Chemical Structure
Tyloxapol, CAS 25301-02-4
Pack Size Availability Price/USD Quantity
200 mg In stock $ 30.00
500 mg In stock $ 45.00
1 g In stock $ 53.00
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Purity: polymer
Purity: polymer
Purity: polymer
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
In vitro Tyloxapol is generally regarded as a safe stabilizer. In some studies, it is reported to causes cytotoxicity in epithelial and red blood cells, induces lysis of human Jurkat T-lymphoblasts and the apoptosis in RAW 264.7 murine macrophage-like cells and NIH/3T3 mouse fibroblast cells. These indications of cytotoxicity, however, do not reflect the in vivo use of Tyloxapol, since it is rarely used alone in clinical applications[3].
In vivo A single intravenous injection of tyloxapol at dose of 400 mg/kg body weight shows three distinctive phases, sharp linear increment, slow linear increment and slow decrement of plasma lipids toward the basal levels[1]. The treatment of tyloxapol enhannces the pulmonary absorption of rh-insulin and increases the absorption of inhaled insulin in diabetic rats. It might significantly increase the hypoglycemic effect of intratracheally administered insulin in diabetic rats but does not change the LDH activity[2].
Cell Research HEK293 cells growing at 40% confluency are exposed to different test dispersions of SLP or their individual components for 48 h and observed the alterations in cellular morphology.(Only for Reference)
Synonyms Triton WR1339
Molecular Weight N/A
CAS No. 25301-02-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 25 mg/mL, sonification is recommended.

DMSO: 38 mg/mL

TargetMolReferences and Literature

1. Rasouli M, et al. J Clin Diagn Res. 2016, 10(6):BF01-5. 2. Zheng J, et al. Chem Pharm Bull (Tokyo). 2010, 58(12):1612-1616. 3. Kristl J, et al. Toxicol Appl Pharmacol. 2008, 232(2):218-225. 4. Guo, Wen, et al. Tyloxapol inhibits RANKL-stimulated osteoclastogenesis and ovariectomized-induced bone loss by restraining NF-κB and MAPK activation. Journal of Orthopaedic Translation . 28 (2021): 148-158.

TargetMolCitations

1. Guo, Wen, et al. Tyloxapol inhibits RANKL-stimulated osteoclastogenesis and ovariectomized-induced bone loss by restraining NF-κB and MAPK activation.. Journal of Orthopaedic Translation. 2021 Apr 10;28:148-158. doi: 10.1016/j.jot.2021.01.005. eCollection 2021 May.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Obesity Compound Library

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Keywords

Tyloxapol 25301-02-4 GPCR/G Protein NF-Κb NF-κB LPL Receptor inhibit Triton WR-1339 Triton WR1339 Triton WR 1339 Inhibitor inhibitor

 

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