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Tyrphostin A1

Catalog No. T7649 CAS 2826-26-8

Synonyms: AG9, Tyrphostin 1

Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .

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Tyrphostin A1, CAS 2826-26-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 47.00
25 mg	In stock	$ 89.00
50 mg	In stock	$ 126.00
100 mg	In stock	$ 163.00
1 mL * 10 mM (in DMSO)	In stock	$ 34.00

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Purity: 99.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .
In vitro	Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.tyrphostin A1 blocks CD40L-induced translocation of NF-kappaB to the nucleus, and reduces the activation of IL-12 p40 gene.?In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells[1].

Synonyms	AG9, Tyrphostin 1
Molecular Weight	184.19
Formula	C11H8N2O
CAS No.	2826-26-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (542.92 mM)

References and Literature

1. Du C , Bright J J , Sriram S . Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice[J]. Journal of Neuroimmunology, 2001, 114(1-2):69-79. 2. Ogura T , Imanishi S , Shibamoto T . Activation of Background Membrane Conductance by the Tyrosine Kinase Inhibitor Tyrphostin A23 and Its Inactive Analog Tyrphostin A1 in Guinea Pig Ventricular Myocytes.[J]. The Japanese Journal of Pharmacology, 2001, 87(3):235-239.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Membrane Protein-targeted Compound Library Tyrosine Kinase Inhibitor Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Angiogenesis related Compound Library Reprogramming Compound Library Anti-Prostate Cancer Compound Library Covalent Inhibitor Library

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Erlotinib hydrochloride PAT-505 EGFR-IN-99 Depatuxizumab Poziotinib ALK-IN-1 Taspine Chrysophanol

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Tyrphostin A1 2826-26-8 Angiogenesis Immunology/Inflammation JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Interleukin Tyrphostin A 1 Interleukin Related Tyrphostin1 inhibit AG-9 Tyrphostin A-1 AG9 Tyrphostin-1 AG 9 Inhibitor Tyrphostin 1 inhibitor

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