Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 43.00 | |
2 mg | In stock | $ 61.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 148.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 848.00 | |
200 mg | In stock | $ 1,150.00 | |
500 mg | In stock | $ 1,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 112.00 |
Description | VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG. |
Targets&IC50 | KCC2:560 nM |
In vitro | VU 0240551 (0-100 μM) reduces the P cell response to GABA in a concentration-dependent manner and significantly reduces GABA-elicited hyperpolarization at doses of 75 and 100 μM[3]. |
In vivo | VU 0240551 (10 μM) significantly blocks the chloride influx in cells from euhydrated rats. VU 0240551 doesn't affect cells from Salt-loading rats[4]. |
Synonyms | N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide, VU0240551-2-D4 |
Molecular Weight | 342.44 |
Formula | C16H14N4OS2 |
CAS No. | 893990-34-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 45 mg/mL (131.4 mM)
You can also refer to dose conversion for different animals. More
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VU 0240551 893990-34-6 Angiogenesis JAK/STAT signaling Membrane transporter/Ion channel Metabolism Tyrosine Kinase/Adaptors Potassium Channel Calcium Channel HER VU0240551 N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU0240551-2-D4 VU-0240551 inhibitor inhibit