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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $43 | In Stock | |
10 mg | $76 | In Stock | |
25 mg | $161 | In Stock | |
50 mg | $278 | In Stock | |
100 mg | $445 | In Stock | |
200 mg | $592 | In Stock | |
1 mL x 10 mM (in DMSO) | $47 | In Stock |
Description | VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG. |
Targets&IC50 | KCC2:560 nM |
In vitro | VU 0240551 (0-100 μM) reduces the P cell response to GABA in a concentration-dependent manner and significantly reduces GABA-elicited hyperpolarization at doses of 75 and 100 μM[3]. |
In vivo | VU 0240551 (10 μM) significantly inhibits chloride influx in cells from euhydrated rats, but does not affect cells from salt-loaded rats[4]. |
Alias | VU0240551-2-D4, N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide |
Molecular Weight | 342.44 |
Formula | C16H14N4OS2 |
Cas No. | 893990-34-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: Insoluble DMSO: 45 mg/mL (131.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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