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VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | 27 € | In Stock | |
5 mg | 45 € | In Stock | |
10 mg | 78 € | In Stock | |
25 mg | 164 € | In Stock | |
50 mg | 272 € | In Stock | |
100 mg | 392 € | In Stock | |
200 mg | 559 € | In Stock | |
1 mL x 10 mM (in DMSO) | 50 € | In Stock |
Description | VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM]. |
Targets&IC50 | mGluR5 (rat):224 nM (Ki), mGluR5 (rat):9 nM (EC50), mGluR1 (rat):557 nM (EC50), mGluR4 (human):154 nM (EC50), mGluR2 (rat):1.5 μM (EC50) |
Alias | VU 29 |
Molecular Weight | 384.39 |
Formula | C22H16N4O3 |
Cas No. | 890764-36-0 |
Smiles | N(C(=O)C1=CC=C(N(=O)=O)C=C1)C=2N(N=C(C2)C3=CC=CC=C3)C4=CC=CC=C4 |
Relative Density. | 1.30 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (65.04 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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