Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 55.00 | |
2 mg | Inquiry | $ 98.00 | |
5 mg | Inquiry | $ 180.00 | |
10 mg | Inquiry | $ 293.00 | |
25 mg | Inquiry | $ 527.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 180.00 |
Description | Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2. |
In vitro | Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4] |
Synonyms | Vosaroxin, AG 7352, SNS-595 |
Molecular Weight | 401.44 |
Formula | C18H19N5O4S |
CAS No. | 175414-77-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (49.82 mM), warmed
H2O: <1 mg/mL
Ethanol: <1 mg/mL
You can also refer to dose conversion for different animals. More
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Voreloxin 175414-77-4 Apoptosis DNA Damage/DNA Repair Topoisomerase Vosaroxin SNS 595 inhibit AG-7352 Inhibitor AG 7352 SNS-595 SNS595 AG7352 inhibitor