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Voreloxin

Catalog No. T6724   CAS 175414-77-4
Synonyms: Vosaroxin, AG 7352, SNS-595

Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.

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Voreloxin Chemical Structure
Voreloxin, CAS 175414-77-4
Pack Size Availability Price/USD Quantity
1 mg Inquiry $ 55.00
2 mg Inquiry $ 98.00
5 mg Inquiry $ 180.00
10 mg Inquiry $ 293.00
25 mg Inquiry $ 527.00
1 mL * 10 mM (in DMSO) Inquiry $ 180.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
In vitro Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4]
Synonyms Vosaroxin, AG 7352, SNS-595
Molecular Weight 401.44
Formula C18H19N5O4S
CAS No. 175414-77-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (49.82 mM), warmed

H2O: <1 mg/mL

Ethanol: <1 mg/mL

TargetMolReferences and Literature

1. Tsuzuki Y, et al. J Med Chem. 2004, 47(8), 2097-2109. 2. Hoch U, et al. Cancer Chemother Pharmacol. 2009, 64(1), 53-65.

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Keywords

Voreloxin 175414-77-4 Apoptosis DNA Damage/DNA Repair Topoisomerase Vosaroxin SNS 595 inhibit AG-7352 Inhibitor AG 7352 SNS-595 SNS595 AG7352 inhibitor

 

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