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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $127 | In Stock | |
5 mg | $260 | In Stock | |
10 mg | $371 | In Stock | |
25 mg | $593 | In Stock | |
50 mg | $848 | In Stock | |
100 mg | $1,170 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines. |
In vitro | MTR-106, stabilizes DNA G-quadruplexes in vitro.?MTR-106 displayed significant antiproliferative activity in homologous recombination repair (HR)-deficient and PARP inhibitor (PARPi)-resistant cancer cells.?Moreover, MTR-106 increased DNA damage and promoted cell cycle arrest and apoptosis to inhibit cell growth. |
In vivo | MTR-106 oral and i.v. administration significantly impaired tumor growth in BRCA-deficient xenograft mouse models.?However, MTR-106 showed modest activity against talazoparib-resistant xenograft models.?In rats, the drug rapidly distributes to tissues within 5 min, and its average concentrations were 12-fold higher in the tissues than in the plasma.?Overall, MTR-106 as a novel G-quadruplex stabilizer with high tissue distribution, and it may serve as a potential anticancer agent. |
Alias | MTR-106 |
Molecular Weight | 525.62 |
Formula | C28H27N7O2S |
Cas No. | 1639357-93-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 5.25 mg/ml (10 mM) H2O: Insoluble | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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