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PDE4B-IN-2
🥰Excellent
Catalog No. T36832Cas No. 915082-52-9
Alias A 33
PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.
PDE4B-IN-2
🥰Excellent
Purity: 99.37%
Catalog No. T36832Alias A 33Cas No. 915082-52-9
PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $113 | In Stock | |
| 25 mg | $228 | In Stock | |
| 50 mg | $372 | In Stock | |
| 100 mg | $597 | In Stock | |
| 500 mg | $1,260 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $79 | In Stock |
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CitedSelect Batch
Purity:99.37%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects. |
| Targets&IC50 | PDE4D:1.7 μM (IC50), PDE4B:15 nM (IC50) |
| In vitro | PDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC50>10 µM) but inhibits LPS-induced TNF-α production in vitro in mouse peripheral blood mononuclear cells (PBMC; IC50=0.5 µM) [1]. |
| In vivo | PDE4B-IN-2 (compound 33; 2 mg/kg; po) achieves a Cmax of 8.7 μg/mL and an AUC of 52.3 μg•h/mL in mice[1]. |
| Alias | A 33 |
| Molecular Weight | 387.88 |
| Formula | C19H18ClN3O2S |
| Cas No. | 915082-52-9 |
| Smiles | CCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(Cl)s1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (58 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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