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Ac2-26 ammonium
Catalog No. T78371
Alias Ac2-26 ammonium (151988-33-9 free base)
Ac2-26 ammonium is an Annexin-A1 (AnxA1) N-terminal derived peptide with anti-inflammatory activity and alleviates liver ischemia-reperfusion injury in mice by regulating IL-22/IL-22R1/STAT3 signaling and eNOS pathways.
Ac2-26 ammonium
Ac2-26 ammonium
Catalog No. T78371Alias Ac2-26 ammonium (151988-33-9 free base)
Ac2-26 ammonium is an Annexin-A1 (AnxA1) N-terminal derived peptide with anti-inflammatory activity and alleviates liver ischemia-reperfusion injury in mice by regulating IL-22/IL-22R1/STAT3 signaling and eNOS pathways.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $123 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $348 | In Stock | |
| 50 mg | $538 | In Stock | |
| 100 mg | $766 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ac2-26 ammonium is an Annexin-A1 (AnxA1) N-terminal derived peptide with anti-inflammatory activity and alleviates liver ischemia-reperfusion injury in mice by regulating IL-22/IL-22R1/STAT3 signaling and eNOS pathways. |
| Targets&IC50 | FPR1 (human):1.4 μM (EC50), FPR2 (human):1.8 μM (EC50) |
| In vitro | In radioligand binding assays, Ac2-26 ammonium was able to bind to HEK293 cells expressing human formyl peptide receptor 1 (FPR1) or FPR2, FPR1 (EC50=1.4 μM) and FPR2 (EC50=1.8 μM). Ac2-26 ammonium inhibited lipopolysaccharide (LPS)-induced prostaglandin (E2) and nitric oxide (NO) production in rat microglia. [1] |
| In vivo | In a rat model of ventilator-induced ischemia-reperfusion injury, Ac2-26 ammonium was able to reduce pulmonary edema when administered at a dose of 0.5-1 mg/kg. [2] |
| Alias | Ac2-26 ammonium (151988-33-9 free base) |
| Molecular Weight | 3089.43 (free base) |
| Formula | C141H210N32O44S.xNH3 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 30 mg/mL (130.18 mM), Sonication is recommended. Adjust pH to 8 and sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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