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Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $213 | In Stock | |
5 mg | $449 | In Stock | |
10 mg | $713 | In Stock |
Description | Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha. |
In vitro | METHODS: ARPE cells were co-cultured with MT2, TL-Om1 or Jurkat cells and treated with Adalimumab (0.1-10 µg/mL) for 48 h. Supernatants were extracted to measure the levels of inflammatory cytokines using CBA human inflammation cytokine kits. RESULTS: The levels of IL-6, IL-10 and IL-8 production did not change with the addition of Adalimumab. adalimumab decreased tumor necrosis factor (TNF) secretion in a concentration-dependent manner, and TNF was not detected at Adalimumab ≥1.0 µg/mL.[1] METHODS: CD4+ T cells were treated with Adalimumab (1 µg/mL) and aCD3/CD28 mAb for 3 days, then stimulated with PMA/ionomycin in the presence of GolgiStop for 3 h. IL-10 expression was detected using mass spectrometry cytometry (CyTOF). RESULTS: Adalimumab treatment resulted in the induction of IL-10 in multiple CD4+ T cell subsets. [2] |
In vivo | METHODS: To study the effects on the human autosomal recessive RP mouse model, Adalimumab (3 mg/kg) was administered intraperitoneally to rd10 mice, a human autosomal recessive retinitis pigmentosa model, every three days for nine days. RESULTS: Adalimumab reduced photoreceptor cell death by scoring the number of TUNEL-positive cells. adalimumab also improved the antioxidant response by restoring total antioxidant capacity and superoxide dismutase activity. adalimumab normalized the energy and metabolism patterns in the retina of rd10 mice. [3] |
Cell Research | Objective: Adalimumab induces apoptosis of THP-1 cells. Concentrations: 10μg/mL. Incubation Time: 6, 12, 18, 24, 30 hours. Method: THP-1 cells (0.5×106) were incubated with anti-FcRI mAb and anti-FcRII mAb, and then cultured with adalimumab, infliximab, huIgG or vehicle (PBS) alone as indicated. LPS (1μg/mL) was added in all culture conditions. Apoptosis was analyzed at different time points by staining with annexin V-FITC and propidium iodide, Apo2.7-PE-conjugated antibody, or 7AAD. |
Animal Research | Objective: The distribution of certolizumab pegol, adalimumab, and infliximab in the inflamed paws of mice with collagen-induced arthritis. Formulation: PBS. Dosages: 2 mg/kg |
Molecular Weight | 145.4 kDa |
Cas No. | 331731-18-1 |
Relative Density. | no data available |
Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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