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Aldoxorubicin

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Aldoxorubicin

Catalog No. T11090LCas No. 1361644-26-9

Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).

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Pack Size	Price	Availability
25 mg	Inquiry	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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Product Introduction

Bioactivity

Description	Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).
In vitro	Aldoxorubicin (0.27 to 2.16 μM) suppresses blood vessel formation. Aldoxorubicin (0.27 to 2.16 μM) also reduces multiple myeloma cell growth in a pH-dependent fashion.
In vivo	Aldoxorubicin displays a good safety profile at doses up to 260 mg/mL doxorubicin equivalents and is able to cause tumor regressions in breast cancer, small cell lung cancer, and sarcoma in phase I study[2]. In a murine renal cell carcinoma model and in breast carcinoma xenograft models, Aldoxorubicin also shows superior activity over doxorubicin [3]. On days 28, Aldoxorubicin (10.8 mg/kg, i.v.) displays obviously smaller tumor volumes and IgG levels, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1].
Alias	DOXO-EMCH, INNO-206

Chemical Properties

Molecular Weight	750.75
Formula	C37H42N4O13
Cas No.	1361644-26-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (99.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3320 mL	6.6600 mL	13.3200 mL	66.6001 mL
5 mM	0.2664 mL	1.3320 mL	2.6640 mL	13.3200 mL
10 mM	0.1332 mL	0.6660 mL	1.3320 mL	6.6600 mL
20 mM	0.0666 mL	0.3330 mL	0.6660 mL	3.3300 mL
50 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3320 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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