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α-Viniferin

Catalog No. TN1378 CAS 62218-13-7

Synonyms: ALPHA-VINIFERIN

α-Viniferin known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin has anti-Alzheimer's disease, anti-tuberculosis, anti-tumor, anti-inflammation, anti-diabetes and other pharmacological activitie

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α-Viniferin, CAS 62218-13-7

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Description	α-Viniferin known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin has anti-Alzheimer's disease, anti-tuberculosis, anti-tumor, anti-inflammation, anti-diabetes and other pharmacological activitie
Targets&IC50	CYP2C19:0.93μM, Mycobacterium tuberculosis:4.6 μM(MIC50), CYP3A4:1.2μM, Macrophages and pneumocytes:2.3-4.6 μM(MIC50)
In vitro	α-Viniferin at 3 - 10 muM dose-dependently inhibited IFN-gamma-induced production of NO, IFN-gamma-inducible protein-10 (IP-10), or the monokine induced by IFN-gamma (MIG) in RAW 264.7 cells and also that of NO in primary macrophages-derived from C57BL/6 mice. Furthermore, α-Viniferin diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10, or MIG as well as inhibited promoter activity of the iNOS gene[1].α-viniferin is a bioactive phytochemical compound obtained from Carex humilis, which has the antitubercular activity. α-Viniferin was active against both drug-susceptible and -resistant strains of Mycobacterium tuberculosis at MIC50s of 4.6 μM in culture broth medium and MIC50s of 2.3-4.6 μM inside macrophages and pneumocytes[2]. α-Viniferin strongly inhibited 7 of the 9 P450 (CYP) isoforms (except CYP2A6 and CYP2E1) in human. α-viniferin strongly inhibited CYP2C19-mediated omeprazole 5-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation with IC50 values of 0.93 and 1.2 μM, respectively[3].
In vivo	Oral bioavailability of α-viniferin in mice was 4.2 %.[4]

Synonyms	ALPHA-VINIFERIN
Molecular Weight	678.68
Formula	C42H30O9
CAS No.	62218-13-7

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lee JY, et al. alpha-Viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages.J Pharmacol Sci. 2010;112(4):405-14. 2. Seo H, et al. In vitro activity of alpha-viniferin isolated from the roots of Carex humilis against Mycobacterium tuberculosis. Pulm Pharmacol Ther. 2017 Oct;46:41-47. 3. Fan Y, et al. Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats. J Pharm Biomed Anal. 2020 Sep 5;188:113376. 4. Sim J, et al. Potent inhibitory effect of alpha-viniferin on human cytochrome P450. Food Chem Toxicol. 2014 Jul;69:276-80.

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Keywords

α-Viniferin 62218-13-7 GPCR/G Protein Immunology/Inflammation Metabolism Prostaglandin Receptor NO Synthase P450 a-Viniferin ALPHA-VINIFERIN alpha Viniferin alphaViniferin inhibitor inhibit

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