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AM-5308
🥰Excellent
Catalog No. T63726Cas No. 2410796-89-1
Alias AM5308
AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.
AM-5308
🥰Excellent
Purity: 99.58%
Catalog No. T63726Alias AM5308Cas No. 2410796-89-1
AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $148 | In Stock | |
| 5 mg | $372 | In Stock | |
| 10 mg | $562 | In Stock | |
| 25 mg | $1,120 | In Stock | |
| 50 mg | $1,780 | In Stock | |
| 100 mg | $2,880 | In Stock |
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Purity:99.58%
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Product Introduction
Bioactivity
Chemical Properties
| Description | AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer. |
| In vitro | AM-5308 and AM-1882 have a favorable in vitro profile against a panel of normal cell types, which is distinct from myelosuppressive and neurotoxic anti-mitotic agents. Nevertheless, higher micromolar concentrations of AM-5308 and AM-1882 may adversely affect normal cells. [1] |
| In vivo | Mice with established tumors were administered vehicle, AM-1882 at 50 or 100 mg per kg or AM-5308 at 25 or 50 mg/kg daily for 18 d. AM-1882 and AM-5308 inhibited tumor growth with evidence of tumor regression. [1] |
| Alias | AM5308 |
| Molecular Weight | 529.65 |
| Formula | C26H35N5O5S |
| Cas No. | 2410796-89-1 |
| Smiles | C(NC=1N=C(C=CC1)N2C[C@@H](C)OCC2)(=O)C3=C(N4CCC5(CC5)CC4)C=C(NS(CCO)(=O)=O)C=C3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (151.04 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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